2023
Finnegan, E., Ding, W., Ude, Z., Terer, S., McGivern, T., Blümel, A. M., Kirwan, G., Shao, X., Genua, F., Yin, X., Kel, A., Fattah, S., Myer, P. A., Cryan, S. A., Prehn, J. H. M., O’Connor, D. P., Brennan, L., Yochum, G., Marmion, C. J., & Das, S. (2023). Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer. Cellular oncology (Dordrecht), 10.1007/s13402-023-00882-x. Advance online publication. https://doi.org/10.1007/s13402-023-00882-x
Cosgrove, N., Eustace, A. J., O’Donovan, P., Madden, S. F., Moran, B., Crown, J., Moulton, B., Morris, P. G., Grogan, L., Breathnach, O., Power, C., Allen, M., Walshe, J. M., Hill, A. D., Blümel, A., O’Connor, D., Das, S., Milewska, M., Fay, J., Kay, E., … Furney, S. J. (2023). Predictive modelling of response to neoadjuvant therapy in HER2+ breast cancer. NPJ breast cancer, 9(1), 72. https://doi.org/10.1038/s41523-023-00572-9
2022
Morgan, M. P., Finnegan, E., & Das, S. (2022). The role of transcription factors in the acquisition of the four latest proposed hallmarks of cancer and corresponding enabling characteristics. Seminars in cancer biology, 86(Pt 3), 1203–1215. https://doi.org/10.1016/j.semcancer.2022.10.002
Myer, P. A., Lee, J. K., Madison, R. W., Pradhan, K., Newberg, J. Y., Isasi, C. R., Klempner, S. J., Frampton, G. M., Ross, J. S., Venstrom, J. M., Schrock, A. B., Das, S., Augenlicht, L., Verma, A., Greally, J. M., Raj, S. M., Goel, S., & Ali, S. M. (2022). The Genomics of Colorectal Cancer in Populations with African and European Ancestry. Cancer discovery, 12(5), 1282–1293. https://doi.org/10.1158/2159-8290.CD-21-0813
Smyth, J. S., Fallon, C. M., Das, S., Foulke‐Abel, J., Quach, A., Donowitz, M., Barrett, K. E., & Keely, S. J. (2022). Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by the Nuclear Bile Acid Receptor, Farnesoid X Receptor. The FASEB Journal, 36(S1), fasebj.2022.36.S1.R6019. https://doi.org/10.1096/fasebj.2022.36.S1.R6019
Miller, I. S., Khan, S., Shiels, L. P., Das, S., O’ Farrell, A. C., Connor, K., Lafferty, A., Moran, B., Isella, C., Loadman, P., Conroy, E., Cohrs, S., Schibli, R., Kerbel, R. S., Gallagher, W. M., Marangoni, E., Bennett, K., O’ Connor, D. P., Dwyer, R. M., & Byrne, A. T. (2022). Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects. Cancer medicine, 11(20), 3820–3836. https://doi.org/10.1002/cam4.4756
Silva, R., Moran, B., Das, S., Mulligan, N., Doughty, M., Treacy, A., Sheahan, K., Kelly, C. M., Duffy, A. G., Perry, A. S., & Brennan, D. J. (2022). Investigating a clinically actionable BRAF mutation for monitoring low-grade serous ovarian cancer: A case report. Case reports in women’s health, 34, e00395. https://doi.org/10.1016/j.crwh.2022.e00395
Myer, P. A., Kim, H., Blümel, A. M., Finnegan, E., Kel, A., Thompson, T. V., Greally, J. M., Prehn, J. H., O’Connor, D. P., Friedman, R. A., Floratos, A., & Das, S. (2022). Master Transcription Regulators and Transcription Factors Regulate Immune-Associated Differences Between Patients of African and European Ancestry With Colorectal Cancer. Gastro hep advances, 1(3), 328–341. https://doi.org/10.1016/j.gastha.2022.01.004
2021
Gallagher, J., Chisale, M., Das, S., Drew, R. J., Glezeva, N., Wildes, D. M., De Gascun, C., Wu, T. J., Ledwidge, M. T., Watson, C., & BIOTOPE team (2021). Aetiology and severity of childhood pneumonia in primary care in Malawi: a cohort study. BMJ open, 11(7), e046633. https://doi.org/10.1136/bmjopen-2020-046633
Reynolds, I. S., O’Connell, E., Fichtner, M., Blümel, A., Mason, S. E., Kinross, J., McNamara, D. A., Kay, E. W., O’Connor, D. P., Das, S., Burke, J. P., & Prehn, J. H. M. (2021). An Insight Into the Driver Mutations and Molecular Mechanisms Underlying Mucinous Adenocarcinoma of the Rectum. Diseases of the colon and rectum, 64(6), 677–688. https://doi.org/10.1097/DCR.0000000000001825
2020
Dwane, L., O’Connor, A. E., Das, S., Moran, B., Mulrane, L., Pinto-Fernandez, A., Ward, E., Blümel, A. M., Cavanagh, B. L., Mooney, B., Dirac, A. M., Jirström, K., Kessler, B. M., Ní Chonghaile, T., Bernards, R., Gallagher, W. M., & O’Connor, D. P. (2020). A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer. Cancer research, 80(22), 5076–5088. https://doi.org/10.1158/0008-5472.CAN-20-0214
Barat, A., Smeets, D., Moran, B., Zhang, W., Cao, S., Das, S., Klinger, R., Betge, J., Murphy, V., Bacon, O., Kay, E. W., Van Grieken, N. C. T., Verheul, H. M. W., Gaiser, T., Schulte, N., Ebert, M. P., Fender, B., Hennessy, B. T., McNamara, D. A., O’Connor, D., … Prehn, J. H. M. (2020). Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer. Scientific reports, 10(1), 9778. https://doi.org/10.1038/s41598-020-65869-2
Annett, S., Moore, G., Short, A., Marshall, A., McCrudden, C., Yakkundi, A., Das, S., McCluggage, W. G., Nelson, L., Harley, I., Moustafa, N., Kennedy, C. J., deFazio, A., Brand, A., Sharma, R., Brennan, D., O’Toole, S., O’Leary, J., Bates, M., O’Riain, C., … Robson, T. (2020). FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer. British journal of cancer, 122(3), 361–371. https://doi.org/10.1038/s41416-019-0649-5
2019
Walsh, L., Haley, K. E., Moran, B., Mooney, B., Tarrant, F., Madden, S. F., Di Grande, A., Fan, Y., Das, S., Rueda, O. M., Dowling, C. M., Varešlija, D., Chin, S. F., Linn, S., Young, L. S., Jirström, K., Crown, J. P., Bernards, R., Caldas, C., Gallagher, W. M., … Ní Chonghaile, T. (2019). BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 25(23), 7139–7150. https://doi.org/10.1158/1078-0432.CCR-19-0713
Glezeva, N., Moran, B., Collier, P., Moravec, C. S., Phelan, D., Donnellan, E., Russell-Hallinan, A., O’Connor, D. P., Gallagher, W. M., Gallagher, J., McDonald, K., Ledwidge, M., Baugh, J., Das, S., & Watson, C. J. (2019). Targeted DNA Methylation Profiling of Human Cardiac Tissue Reveals Novel Epigenetic Traits and Gene Deregulation Across Different Heart Failure Patient Subtypes. Circulation. Heart failure, 12(3), e005765. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005765
2018
Smeets, D., Miller, I. S., O’Connor, D. P., Das, S., Moran, B., Boeckx, B., Gaiser, T., Betge, J., Barat, A., Klinger, R., van Grieken, N. C. T., Cremolini, C., Prenen, H., Mazzone, M., Depreeuw, J., Bacon, O., Fender, B., Brady, J., Hennessy, B. T., McNamara, D. A., … Byrne, A. T. (2018). Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy. Nature communications, 9(1), 4112. https://doi.org/10.1038/s41467-018-06567-6
Ward, E., Varešlija, D., Charmsaz, S., Fagan, A., Browne, A. L., Cosgrove, N., Cocchiglia, S., Purcell, S. P., Hudson, L., Das, S., O’Connor, D., O’Halloran, P. J., Sims, A. H., Hill, A. D., & Young, L. S. (2018). Epigenome-wide SRC-1-Mediated Gene Silencing Represses Cellular Differentiation in Advanced Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 24(15), 3692–3703. https://doi.org/10.1158/1078-0432.CCR-17-2615
Varešlija, D., Priedigkeit, N., Fagan, A., Purcell, S., Cosgrove, N., O’Halloran, P. J., Ward, E., Cocchiglia, S., Hartmaier, R., Castro, C. A., Zhu, L., Tseng, G. C., Lucas, P. C., Puhalla, S. L., Brufsky, A. M., Hamilton, R. L., Mathew, A., Leone, J. P., Basudan, A., Hudson, L., … Young, L. S. (2019). Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets. Journal of the National Cancer Institute, 111(4), 388–398. https://doi.org/10.1093/jnci/djy110
van Dijk, E., Biesma, H. D., Cordes, M., Smeets, D., Neerincx, M., Das, S., Eijk, P. P., Murphy, V., Barat, A., Bacon, O., Prehn, J. H. M., Betge, J., Gaiser, T., Fender, B., Meijer, G. A., McNamara, D. A., Klinger, R., Koopman, M., Ebert, M. P. A., Kay, E. W., … Ylstra, B. (2018). Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 36(20), 2052–2060. https://doi.org/10.1200/JCO.2017.77.1782
2017
Das, S., Moran, B., & Perry, A. S. (2018). Assessing DNA Methylation in Cancer Stem Cells. Methods in molecular biology (Clifton, N.J.), 1692, 157–178. https://doi.org/10.1007/978-1-4939-7401-6_15
Streubel, G., Fitzpatrick, D. J., Oliviero, G., Scelfo, A., Moran, B., Das, S., Munawar, N., Watson, A., Wynne, K., Negri, G. L., Dillon, E. T., Jammula, S., Hokamp, K., O’Connor, D. P., Pasini, D., Cagney, G., & Bracken, A. P. (2017). Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. The EMBO journal, 36(15), 2216–2232. https://doi.org/10.15252/embj.201696307
Das, S., Kelly, D., Moran, B., Han, K., Mulligan, N., Barrett, C., Buckley, P. G., McMahon, P., McCaffrey, J., Van Essen, H. F., Connor, K., Lambrechts, D., Ylstra, B., Gallagher, W. M., O’Connor, D. P., & Kelly, C. M. (2017). Postmortem Examination of an Aggressive Case of Medullary Thyroid Carcinoma Characterized by Catastrophic Genomic Abnormalities. JCO precision oncology, 1, PO.16.00063. https://doi.org/10.1200/PO.16.00063
Moran, B., Das, S., Smeets, D., Peutman, G., Klinger, R., Fender, B., Connor, K., Ebert, M., Gaiser, T., Prehn, J. H., Bacon, O., Kay, E., Hennessy, B., Murphy, V., Ylstra, B., Lambrechts, D., Byrne, A. T., Gallagher, W. M., & O’Connor, D. P. (2017). Assessment of concordance between fresh-frozen and formalin-fixed paraffin-embedded tumour DNA methylation using a targeted sequencing approach. Oncotarget, 8(29), 48126–48137. https://doi.org/10.18632/oncotarget.18296
EpiGastroDRG 